Vrije Universiteit Brussel

 

Publications on Stem Cells

Migration of culture-expanded human mesenchymal stem cells (MSC) through bone marrow endothelium is regulated by matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-3 (TIMP-3)
  • Migration of culture-expanded human mesenchymal stem cells (MSC) through bone marrow endothelium is regulated by matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-3 (TIMP-3).

    De Becker A, Van Hummelen P, Bakkus M, Vande Broek I, De Wever J, De Waele M, Van Riet I.

    Haematologica 92 (4), 440-9, 2007.

    Abstract:
    Mesenchymal stem cells (MSC) are adult stem cells that can be expanded many fold in vitro and have the therapeutic potential to restore the bone marrow microenvironment and support hematopoietic recovery after myeloablative conditioning for hematopoietic stem cell transplantation. Successful homing to the target tissue, such as bone marrow, implies that MSC are able to extravasate after systemic administration

 

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