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Publications on Multiple Myeloma

Two monoclonal antibodies (OKIa1 and OKT10) for the study of the final B cell maturation
  • Two monoclonal antibodies (OKIa1 and OKT10) for the study of the final B cell maturation.

    Van Camp, B, Thielemans, C, Dehou, MF, De Mey, J, De Waele, M.

    J Clin Immunol 2 (3 Suppl), 67S-74S, 1982.

    Abstract:
    OKT10 is a monoclonal antibody which recognizes an antigenic structure of 45,000 daltons which is present on precursor T and B cells, activated T cells and some monocytes. In this study, this antibody was shown to react strongly with the surface membrane of plasma cells. In addition, OKT10 can be used to study final B cell maturation since the OKT10 antigen is expressed on mature lymphocytes and lymphoplasmacytic cells. Acquisition of OKT10 reactivity occurs in an inverse or opposite relationship to the presence of Ia-like antigenic expression. Therefore, these two antigens can be employed as complementary opposite reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenstrom malignancy.

 

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