Vrije Universiteit Brussel


Publications on Multiple Myeloma

Multiple Myeloma, an update on diagnosis and treatment
  • Multiple Myeloma, an update on diagnosis and treatment.

    Caers J, Vande Broek I, De Raeve H, Michaux L, Trullemans F, Schots R, Van Camp B, Vanderkerken K.

    Eur J Haematol Jul 11 ([Epub ahead of print]), , 2008.

    Multiple myeloma is a plasma cell malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow and the production of large amounts of a monoclonal immunoglobulin or paraprotein. In the past years, new approaches in the diagnosis and treatment were introduced aiming to identify high risk patients who need proper anti-myeloma treatment. Intensive therapy including autologous hematopoietic stem cell transplantation and the new agents bortezomib, thalidomide and lenalidomide have improved patients responses. Further optimalisation of the different treatment schedules in well defined patient groups may prolong their survival. Patient stratification is currently based on patient characteristics, extend of myeloma disease and associated cytogenetic and laboratory anomalies. More and more gene expression studies are introduced to stratify patients and to individualize therapy.


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